Friday, March 14, 2008
Decisions Upon Leukemia Treatment
Very often persons without any disease symptoms whatsoever are diagnosed with chronic myeloid Leukemia during a routine blood testing. Unlike the acute forms of Leukemia, the chronic form develops an increased number of white blood cells which can still work normally in spite of their high rate of division. This aspect is responsible of the mild onset of the disease but the negative impact is due to the impossible stopping of the white cell production.
The most effective treatment in these cases is a bone marrow transplant that still implicates risks that make it inaccessible to many of the Leukemia patients. A series of other different therapy methods are available that mostly implicate high challenges in deciding upon the right one.
The increased production of immunity white blood cells is caused by an abnormal chromosome called Philadelphia that allows the bone marrow to produce irregular cells with a very rapid multiplication rate inside the bloodstream. Most of the chronic myeloid patients are taken by surprise by diagnose as they have no clinical manifestations.
The actual development of the disease is mostly unknown but physicians usually use the number of white blood cells to predict the further course of the Leukemia; a further identification of abnormal cells inside the bone marrow has a negative prognosis. Another important clinical sign is the increase of some organ’s size (especially spleen) due to an accumulation of white cells inside their tissues.
The most efficient treatment is the injection of healthy cells from a compatible donor inside the bone marrow. It has the highest chances of curing the patients but also the most many side-effects. The second therapy method is the targeted therapy with Gleevec but its curative potential is not yet well established as it has been available only since 2001. A treatment way with benefic results until this time is the immune sustaining Interferon. Other possible cures are in course of development but are not yet approved.
Patients requesting a treatment for Leukemia always expect to be cured after the therapy. The most efficient treatment is the bone marrow transplant with also the most high risks and side-effects. Other possible cures are still in process of experimentation and their capacity to provide a definitive cure is unknown. A series of years are required to determine their exact benefit.
A patient choosing to undergo a bone marrow transplant must be matched with an available donor and take a cure with immuno depressives who may cause a series of infections due to the decreased capacity of defense of the organism. A patient must be well informed about the risk and the cure statistics before choosing to suffer a transplant. This therapy is the most appropriate for young patients but is not recommended for elder persons with other pathological conditions.
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